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Product Information:

KB02-SLF

KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF.

Cat. No.: EX-A7595    Purity: >98%
Chemical
Chemical structure of KB02-SLF


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg700Inquire
100mg950Inquire
250mg1800Inquire
500mgget quoteIn-stock
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CAS No.2384184-40-9
Purity>98%
FormulaC50H65ClN4O12
Mol Weight949.524
ColorWhite to yellow
Statesolid powder
SolubilityDMSO : 100 mg/mL
Shelf Life>2 years if stored properly
StoragePowder 4℃, sealed storage, away from moisture and light In solvent : -80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

CoACoA of KB02-SLF

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