KAG-308

KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor .


Cat. No.: EX-A8600	Purity: >98%

	Chemical structure of KAG-308

For research only, Do not use for Human!

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CAS No.	1215192-68-9
Purity	>98%
Formula	C24H30F2N4O3
Mol Weight	460.5168
Color	White to light yellow
State	solid powder
Solubility	DMSO : 80 mg/mL H2O : < 0.1 mg/mL
Shelf Life	>3 years if stored properly
Storage	-20°C, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Watanabe Y, et al. KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. Eur J Pharmacol. 2015 May 5;754:179-89.
CoA	CoA of KAG-308

Smiles:	O[C@H](C1)[C@H](/C=C/[C@@H](O)[C@@H](C2=CC=CC(C)=C2)C)[C@](C/3(F)F)([H])[C@@]1([H])OC3=C/CCCC4=NN=NN4


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