K-7174 dihydrochloride

K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer.


Cat. No.: EX-A8130A	Purity: >98%

	Chemical structure of K-7174 dihydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	650	In-stock
200mg	950	In-stock
500mg	1550	In-stock
1g	2450	In-stock

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CAS No.	191089-60-8
Purity	>98%
Formula	C33H50Cl2N2O6
Mol Weight	641.666
Color	White to yellow
State	solid powder
Solubility	DMSO : 100 mg/mL H2O : 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4. [2]. Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep;17(12):1742-4. [3]. Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602.
CoA	CoA of K-7174 dihydrochloride


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