JYP0322

Fudotinib (JYP0322) (ROS1-IN-3) is a potent orally active, selective, and CNS-penetrant ROS1 inhibitor. Fudotinib selectively inhibits human wild-type ROS1 and human ROS1 G2032R with IC50s of 0.37 and 0.3 nM, respectively, showing 6-130-fold selectivity over TRKA, TRKB, and TRKC. Fudotinib inhibits proliferation of ROS1 fusion-expressing cells, and inhibits tumor growth in mouse xenograft models. Fudotinib can be used for the research of non-small cell lung cancer (NSCLC) .


Cat. No.: EX-A16790	Purity: >98%

	Chemical structure of JYP0322

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
5mg	478	Inquire
10mg	625	Inquire

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Synonyms	ROS1-IN-3
Synonyms 2	JYP0322
CAS No.	2644645-39-4
Purity	>98%
Formula	C20H16FN7O3
Mol Weight	421.3845

Reference:	[1].Ma Y, et al. JYP0322, a highly selective and brain-penetrant ROS1 inhibitor, overcomes ROS1^G2032R resistance mutation in NSCLC: The first-in-human phase 1 trial. Cancer Cell. Published online April 23, 2026.
CoA	CoA of JYP0322

Smiles:	O=C1NC2(CC2)COC=3C([C@@]4(N(C5=NC6=C1C(C#N)=NN6C=C5)OCC4)[H])=CC(F)=CN3


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