JWZ-5-13

JWZ-5-13 is a CDK7 PROTAC degrader. JWZ-5-13 inhibits the proliferation of cancer cells. JWZ-5-13 is applicable to the research of ovarian cancer, diffuse large B-cell lymphoma, acute T-lymphoblastic leukemia and non-small cell lung cancer.


Cat. No.: EX-A11996	Purity: >98%

	Chemical structure of JWZ-5-13

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	3120	Inquire
100mg	4550	Inquire
250mg	get quote	Inquire
500mg	get quote	Inquire

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CAS No.	3103763-70-5
Purity	>98%
Formula	C54H66N10O6S
Mol Weight	983.23
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ji W, et al. Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7). Eur J Med Chem. 2024;276:116613.
CoA	CoA of JWZ-5-13

Smiles:	CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCC#CC4=CC=C(C=C4)C(=O)NC5=NNC6=C5CN(C6(C)C)C(=O)N[C@H](CN(C)C)C7=CC=CC=C7)O


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