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Product Information:

JT010

JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research.

Cat. No.: EX-A6706    Purity: >98%
Chemical
Chemical structure of JT010


For research only, Do not use for Human!

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CAS No.917562-33-5
Purity>98%
FormulaC16H19ClN2O3S
Mol Weight354.852
ColorLight yellow to yellow
Statesolid powder
SolubilitySoluble in DMSO 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.

[2]. Szabó K, et al. TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation. Biomolecules. 2024 May 28;14(6):632.

[3]. Matsubara M, et al. Potent Activation of Human but Not Mouse TRPA1 by JT010. Int J Mol Sci. 2022 Nov 18;23(22):14297.

[4]. Virk HS, et al. TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels. Br J Pharmacol. 2021 Aug;178(15):2948-2962.

[5]. Singh U, et al. Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach. Clin Exp Allergy. 2025 Jan 21.

[6]. Hoebart C, Kiss A, Pilz PM, Szabo PL, Podesser BK, Fischer MJM, Heber S. TRPA1 as Target in Myocardial Infarction. Int J Mol Sci. 2023 Jan 28;24(3):2516.

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