JSH-150 dimaleate

JSH-009 (JSH-150) is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation. JSH-009 demonstrated significant in vitro and in vivo efficacy against acute myeloid leukemia (AML).


Cat. No.: EX-A9179A	Purity: >98%

	Chemical structure of JSH-150 dimaleate

For research only, Do not use for Human!

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Synonyms	tambiciclib dimaleate
Synonyms 2	GFH009 dimaleate
CAS No.	2559759-04-3
Purity	>98%
Formula	C33H43ClN6O10S
Mol Weight	751.247
Color	white to yellow
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang L, et al. Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models. Invest New Drugs. 2020 Oct;38(5):1272-1281. [1]. Wang, Beilei et al. “Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.” European journal of medicinal chemistry vol. 158 (2018): 896-916. doi:10.1016/j.ejmech.2018.09.025
CoA	CoA of JSH-150 dimaleate

Smiles:	C(=C\C(O)=O)\C(O)=O.C(NC1=NC(=CS1)C=2C=C(N[C@@H]3CC[C@@H](N[C@@H](COC)C)CC3)N=CC2Cl)C4(C#N)CCOCC4


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