JPHM-2-167

JPHM-2-167 (Compound 11) is a selective PHD (prolyl hydroxylase domain enzyme) inhibitor. JPHM-2-167 inhibits PHD2, PHD3 with IC50s of 0.253 μM and 3.95 μM, respectively. JPHM-2-167 can be used for chronic kidney disease .


Cat. No.: EX-A12995	Purity: >98%

	Chemical structure of JPHM-2-167

For research only, Do not use for Human!

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CAS No.	1258877-17-6
Purity	>98%
Formula	C30H28N6O2
Mol Weight	504.5823
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 25;67(2):1393-1405.
CoA	CoA of JPHM-2-167

Smiles:	O=C1N(C=2C=CC(=CC2)C=3C=CC=CC3)C(=O)C4(N1C5=NC=CC=N5)CCN(CC6=NC=CC=C6C)CC4


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