JP1302 dihydrochloride

JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research.


Cat. No.: EX-A10934	Purity: >98%

	Chemical structure of JP1302 dihydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	480	In-stock
250mg	768	In-stock
500mg	1120	In-stock
1g	1650	In-stock

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CAS No.	1259314-65-2
Purity	>98%
Formula	C24H26Cl2N4
Mol Weight	441.396
Color	Brown to reddish brown
State	Solid
Solubility	H2O : 12.5 mg/mL DMSO : 5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150(4):381-2. [2]. Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402. [3]. Shimokawa T, et al. Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats. J Pharmacol Sci. 2019 Mar;139(3):137-142.
CoA	CoA of JP1302 dihydrochloride

Smiles:	CN1CCN(C2=CC=C(NC3=C(C=CC=C4)C4=NC5=CC=CC=C53)C=C2)CC1.[H]Cl.[H]Cl


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