JP-153

JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.


Cat. No.: EX-A7670	Purity: >98%

	Chemical structure of JP-153

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	650	Inquire
50mg	950	Inquire
100mg	1350	Inquire
1g	get quote	Inquire
5g	get quote	Inquire

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CAS No.	1802937-26-3
Purity	>98%
Formula	C21H19NO5
Mol Weight	365.3793
Color	Pale purple to light pink
State	solid
Solubility	DMSO : ? 200 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Toutounchian JJ, et al. Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Mol Pharmacol. 2017 Jan;91(1):1-13. doi: 10.1124/mol.116.105031. Epub 2016 Nov 9. Erratum in: Mol Pharmacol. 2017 Dec;92(6):627.
CoA	CoA of JP-153


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