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Product Information:

JNK3 inhibitor-1

JNK3 inhibitor-1 is a potent and selective JNK3 inhibitor (IC50 = 0.005 μM). JNK3 inhibitor-1 is orally bioavailable and brain penetrant.

Cat. No.: EX-A13760    Purity: >98%
Chemical
Chemical structure of JNK3 inhibitor-1


For research only, Do not use for Human!

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CAS No.2622877-97-6
Purity>98%
FormulaC21H17ClFN5O2S
Mol Weight457.908
ColorWhite to off-white
StateSolid
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, 3 years, 4°C, 2 years; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Feng Y, et al. N-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors. ACS Med Chem Lett. 2021 Sep 21;12(10):1546-1552.

CoACoA of JNK3 inhibitor-1
Smiles:O=C(C1=CC(N2N=CC3=CC(NC4=C(F)C=CC=C4Cl)=C(C)N=C32)=CS1)NC5COC5

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