JNK-IN-14

JNK-IN-14 is a potent and selective JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 can be used for cancer research


Cat. No.: EX-A12931	Purity: >98%

	Chemical structure of JNK-IN-14

For research only, Do not use for Human!

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CAS No.	2991432-56-3
Purity	>98%
Formula	C27H31N5O4S
Mol Weight	521.631
Color	White to off-white
State	Solid
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, stored under nitrogen; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Karim I Mersal, et al. Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.Eur J Med Chem. 2023 Sep 15:261:115779.
CoA	CoA of JNK-IN-14

Smiles:	O=S(=O)(NCCCNC1=NC=CC(=C1)C2=CN(N=C2C=3C=CC=C(O)C3)C(C)(C)C)C4=CC=C(O)C=C4


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