JNJ-63576253

JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).


Cat. No.: EX-A5158	Purity: >98%

	Chemical structure of JNJ-63576253

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	685	In-stock
500mg	950	In-stock
1g	1350	In-stock
5g	3900	In-stock
10g	5900	In-stock

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Synonyms	TRC-253
CAS No.	2110428-64-1
Purity	>98%
Formula	C23H22ClF3N6O2S
Mol Weight	538.973
Color	Off-white to light yellow
State	solid powder
Solubility	Soluble in DMSO 250 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang Z, et, al. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC). J Med Chem. 2021 Jan 28;64(2):909-924.
CoA	CoA of JNJ-63576253

Smiles:	[H]Cl.O=C(N(C(N1C2=CC=C(N=C2)OC3CCNCC3)=S)C(C=C4C(F)(F)F)=CN=C4C#N)C51CCC5


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