JNJ 55511118

JNJ-55511118 is a selective TARP γ-8 binding AMPA receptor modulator with oral bioavailability and blood-brain barrier permeability, with a Ki of 26 nM. JNJ-55511118 reduces voluntary intake of sweetened alcohol in male mice. In rodent models, JNJ-55511118 inhibits hippocampal neurotransmission, reduces specific electroencephalogram frequency bands, induces transient hyperlocomotion, impairs learning and memory abilities, and exerts anticonvulsant effects. JNJ-55511118 is applicable to research related to alcohol use disorder and seizures.


Cat. No.: EX-A14200	Purity: >98%

	Chemical structure of JNJ 55511118

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	620	In-stock
250mg	920	In-stock
500mg	1320	Inquire
1g	1820	Inquire

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CAS No.	2036081-86-2
Purity	>98%
Formula	C14H8ClF3N2O2
Mol Weight	328.674
Color	White to off-white
State	Solid
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hoffman JL, et al. Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin Exp Res. 2021;45(7):1424-1435. [2]. Maher MP, et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016;357(2):394-414.
CoA	CoA of JNJ 55511118

Smiles:	C1=CC(=C(C(=C1)Cl)C2=CC3=C(C=C2)NC(=O)N3)OC(F)(F)F


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