JNJ-54175446

JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.


Cat. No.: EX-A6857	Purity: >98%

	Chemical structure of JNJ-54175446

For research only, Do not use for Human!

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CAS No.	1627902-21-9
Purity	>98%
Formula	C18H13ClF4N6O
Mol Weight	440.782
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO 62.5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Letavic MA, et al. 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate. Send to
CoA	CoA of JNJ-54175446


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