JNJ-46281222

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71) .


Cat. No.: EX-A7783	Purity: >98%

	Chemical structure of JNJ-46281222

For research only, Do not use for Human!

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CAS No.	1254980-38-5
Purity	>98%
Formula	C23H25F3N4
Mol Weight	414.4666
Color	white to off-white
State	solid powder
Solubility	DMSO : 62.5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600.
CoA	CoA of JNJ-46281222

Smiles:	C1CC1CC2=NN=C3N2C=CC(=C3C(F)(F)F)CN4CCC(CC4)C5=CC=CC=C5


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