JNJ 28871063 hydrochloride

JNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive pan-ErbB kinase inhibitor with IC50 values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. JNJ28871063 hydrochloride inhibits phosphorylation of functionally important tyrosine residues in both EGFR and ErbB2. JNJ28871063 hydrochloride crosses the blood-brain barrier and has antitumor activity in human tumor xenograft models that overexpress EGFR and ErbB2[1].


Cat. No.: EX-A15401	Purity: >98%

	Chemical structure of JNJ 28871063 hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	545	in-stock
50mg	845	in-stock
100mg	1385	in-stock

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CAS No.	944342-90-9
Purity	>98%
Formula	C24H28Cl2N6O3
Mol Weight	519.424
Color	Light yellow to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Stuart L Emanuel, et al. Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol Pharmacol. 2008 Feb;73(2):338-48.
CoA	CoA of JNJ 28871063 hydrochloride

Smiles:	C1COCCN1CCO/N=C/C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N.Cl


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