JNJ-28583113

JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia.


Cat. No.: EX-A11310	Purity: >98%

	Chemical structure of JNJ-28583113

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	620	Inquire
250mg	992	In-stock
500mg	1380	In-stock
1g	1880	In-stock

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CAS No.	2765255-93-2
Purity	>98%
Formula	C19H21F3N2O2
Mol Weight	366.3774
Color	White to off-white
State	solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Fourgeaud L, et al. Pharmacology of JNJ-28583113: A novel TRPM2 antagonist. Eur J Pharmacol. 2019 Jun 15;853:299-307.
CoA	CoA of JNJ-28583113

Smiles:	CCOC(=O)CN1C2=C(CCCCC2)C(=N1)C3=CC=C(C=C3)C(F)(F)F


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