(-)-JJ-450

(-)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR). (-)-JJ-450 is more potent than (+)-JJ-450 in inhibiting androgen-induced AR activity, and the mechanism of AR inhibition by (+)-JJ-450 is different from that of Enzalutamide (MDV3100), which may target the ligand binding domain (LBD) of AR. (-)-JJ-450 inhibits the transcriptional activity of wild-type AR and mutant ARF876L by inhibiting AR nuclear translocation and promoting nuclear degradation of unbound AR. (-)-JJ-450 can be used in the study of castration-resistant prostate cancer (CRPC) resistant to Enzalutamide.


Cat. No.: EX-A13644	Purity: >98%

	Chemical structure of (-)-JJ-450

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
50mg	get quote
100mg	get quote
500mg	get quote
1g	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	1998094-23-7
Purity	>98%
Formula	C21H22ClFN2O
Mol Weight	372.864
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cole RN, et al. (+)-JJ-74-138 is a Novel Noncompetitive Androgen Receptor Antagonist. Mol Cancer Ther. 2022 Apr 1;21(4):483-492.
CoA	CoA of (-)-JJ-450

Smiles:	O=C([C@H]1C[C@H]1C2=CC=C(C=C2)F)N3CCN(CC3)C4=CC(Cl)=CC=C4C


		Search