JH-X-119-01

Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88.


Cat. No.: EX-A5245	Purity: >98%

	Chemical structure of JH-X-119-01

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	385	In-stock
10mg	485	In-stock
50mg	750	In-stock
100mg	1085	In-stock
200mg	1585	In-stock

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CAS No.	2227368-54-7
Purity	>98%
Formula	C25H20N6O3
Mol Weight	452.4647
Color	Light yellow to brown
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pan B, et al. Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice. Int Immunopharmacol. 2020 Aug;85:106597. doi: 10.1016/j.intimp.2020.106597. Epub 2020 May 13. PMID: 32422509.
CoA	CoA of JH-X-119-01

Smiles:	O=C(C=C)NC1=CC=CC(C(NC2=CC=C(NC(C3=NC(C4=CC=NN4)=CC=C3)=O)C=C2)=O)=C1


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