JBJ-03-142-02

EGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC) .


Cat. No.: EX-A7265	Purity: >98%

	Chemical structure of JBJ-03-142-02

For research only, Do not use for Human!

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CAS No.	2068806-31-3
Purity	>98%
Formula	C25H22FN7O3
Mol Weight	487.4857
Color	White to off-white
State	solid powder
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent , -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Jang J,et al. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11629-11633.
CoA	CoA of JBJ-03-142-02


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