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Product Information:

JAK3 covalent inhibitor-2

JAK3 covalent inhibitor-2 (compound J1b) is a selective, orally potent JAK3 inhibitor (IC50=7.2 nM) with low toxicity, anti-inflammatory activity and good bioavailability.

Cat. No.: EX-A12019    Purity: >98%
Chemical
Chemical structure of JAK3 covalent inhibitor-2


For research only, Do not use for Human!

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CAS No.2664050-97-7
Purity>98%
FormulaC20H20N6O3
Mol Weight392.4112
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Hualiang Y et al. Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis ARCH PHARM. 2024 Feb e2300753

CoACoA of JAK3 covalent inhibitor-2
Smiles:N(=O)(=O)C=1C=C(C=2C3=C(N=CN=C3NC2)N4C[C@H](NC(C=C)=O)CCC4)C=CC1

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