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Product Information:

JAK-IN-27

JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM).

Cat. No.: EX-A11819    Purity: >98%
Chemical
Chemical structure of JAK-IN-27


For research only, Do not use for Human!

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CAS No.2673176-36-6
Purity>98%
FormulaC20H21F2N7O
Mol Weight413.4238
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.

CoACoA of JAK-IN-27
Smiles:CN1C=C(C=N1)C2=CN3C(=CC=N3)C(=N2)N4CC5CCC(C4)N5C(=O)[C@@H]6CC6(F)F

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