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Product Information:

ITMN 4077

ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC50: 2131 nM).

Cat. No.: EX-A13095    Purity: >98%
Chemical
Chemical structure of ITMN 4077


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g300In-stock
5g1350In-stock
10g2350In-stock


CAS No.790305-05-4
Purity>98%
FormulaC26H40N4O8S
Mol Weight568.683
ColorWhite to off-white
Statesolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, protect from light; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Rajagopalan R, et al. Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN-191 reveals tight binding and slow dissociative behavior. Biochemistry. 2009 Mar 24;48(11):2559-68.

[2]. Jiang Y, et al. Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease. J Med Chem. 2014 Mar 13;57(5):1753-69.

CoACoA of ITMN 4077
Smiles:O=C(N1)[C@@H]2C[C@@H](O)CN2C([C@@H](NC(OC(C)(C)C)=O)CCCCC/C=C\[C@H](C3)[C@]13C(NS(C4CC4)(=O)=O)=O)=O

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