ISM5939

ISM5939 is an orally active and selective ENPP1 inhibitor with an IC50 of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity.


Cat. No.: EX-A13603	Purity: >98%

	Chemical structure of ISM5939

For research only, Do not use for Human!

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CAS No.	2965301-60-2
Purity	>98%
Formula	C20H18FN5O3S
Mol Weight	427.452
Color	White to off-white
State	Solid
Solubility	DMSO : 200 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pu C, et al. Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors. Nat Commun. 2025 May 23;16(1):4793.
CoA	CoA of ISM5939

Smiles:	COC1=C(C2=CC=CC=C2)C3=C(C=N1)N=C(C)N3CC4=C(F)C=C(S(N)(=O)=O)C=N4


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