Irpagratinib

Irpagratinib (ABSK011) is an orally active inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinase, targeting to FGFR4 (IC50<10 nM). Irpagratinib inhibits the auto-phosphorylation of FGFR4 and blocks signal transduction from FGFR4 to downstream pathway activation.


Cat. No.: EX-A8168	Purity: >98%

	Chemical structure of Irpagratinib

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	800	In-stock
500mg	1500	In-stock
1g	2800	In-stock
5g	get quote	In-stock
1g	get quote	Inquire

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Synonyms	ABSK011
CAS No.	2230974-62-4
Purity	>98%
Formula	C28H32F2N6O5
Mol Weight	570.5877
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chen Z. Abstract LB-272: Discovery and characterization of a novel FGFR4 Inhibitor for the treatment of hepatocellular carcinoma[J]. Cancer Research, 2018, 78(13_Supplement): LB-272-LB-272.
CoA	CoA of Irpagratinib

Smiles:	FC(C(OC)=CC(OC)=C1F)=C1C2=CC(C=N3)=C(C(N4CC(C)(C4)OC)=N2)N=C3N[C@H]5[C@H](CCOC5)NC(C=C)=O


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