IRF5-CPP5

IRF5-CPP5 is a cytosolic peptide that selectively targeting human IRF5 wirh a Kd of 0.53 μM. IRF5-CPP5 disrupts IRF5 homodimerization and inhibits its nuclear translocation without altering IRF5 phosphorylation levels. IRF5-CPP5 inhibits proinflammatory cytokine (IL-6, IL-1β, TNF-α) production. IRF5-CPP5 can be used for the research of systemic lupus erythematosus .


Cat. No.: EX-A16801	Purity: >98%

	Chemical structure of IRF5-CPP5

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1mg	480	Inquire
5mg	550	Inquire
10mg	650	Inquire
100mg	2550	Inquire

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CAS No.	1601299-92-6
Purity	>98%
Formula	C160H245N37O36S
Mol Weight	3294.949
Color	White to off-white
State	solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>1 years if stored properly
Storage	Powder-20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Banga J, et al. Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization[J]. Science advances, 2020, 6(20): eaay1057.
CoA	CoA of IRF5-CPP5

Smiles:	C([C@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC([C@H](CC5=CC=C(O)C=C5)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)C)=O)CC(N)=O)=O)CC(C)C)=O)=O)=O)


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