IRE1α kinase-IN-2

IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines.


Cat. No.: EX-A13769	Purity: >98%

	Chemical structure of IRE1α kinase-IN-2

For research only, Do not use for Human!

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CAS No.	1414938-21-8
Purity	>98%
Formula	C27H23F3N6O
Mol Weight	504.5063
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years, 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang L, Perera BG, Hari SB, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012;8(12):982-989.
CoA	CoA of IRE1α kinase-IN-2

Smiles:	NC1=NC=CN2C1=C(C(C3=C4C=CC=C3)=CC=C4NC(NC5=CC(C(F)(F)F)=CC=C5)=O)N=C2C(C)C


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