Ipomoeassin F

Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .


Cat. No.: EX-A15949	Purity: >98%

	Chemical structure of Ipomoeassin F

For research only, Do not use for Human!

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Synonyms	Ipom-F
CAS No.	915392-44-8
Purity	>98%
Formula	C44H62O15
Mol Weight	830.9541
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Peristera Roboti, et al.Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis. Sci Rep. 2021 Jun 2;11(1):11562. [2]. Shugeng Cao, et al. Ipomoeassin F, a new cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest.Nat Prod Res. 2007 Aug;21(10):872-6. [3]. Sarah O'Keefe, et al. Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor. J Cell Sci. 2021 Feb 19;134(4):jcs257758.
CoA	CoA of Ipomoeassin F

Smiles:	O(C(/C=C/C1=CC=CC=C1)=O)[C@H]2[C@H](OC(/C(=C/C)/C)=O)[C@@H](O)[C@]3(O[C@@]2(COC(=O)CCC(=O)CCCCCC[C@H](CCCCC)O[C@]4([C@](O3)([C@@H](O)[C@@H](OC(C)=O)[C@@H](C)O4)[H])[H])[H])[H]


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