IPN60090 dihydrochloride

IPN-60090 dihydrochloride is an orally active and highly selective inhibitor of glutaminase 1 (GLS1; IC50=31 nM), with no activity observed against GLS-2. IPN-60090 dihydrochloride exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 dihydrochloride can be used for solid tumors research, such as lung and ovarian cancers.


Cat. No.: EX-A8645A	Purity: >98%

	Chemical structure of IPN60090 dihydrochloride

For research only, Do not use for Human!

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CAS No.	2102101-72-2
Purity	>98%
Formula	C24H29Cl2F3N8O3
Mol Weight	605.44
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 170 mg/mL H2O : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	4°C, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2. [2].Michael J Soth, et al. Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. J Med Chem. 2020 Nov 12;63(21):12957-12977.
CoA	CoA of IPN60090 dihydrochloride

Smiles:	O=C(NC)C1=CN(C[C@H](F)CCC2=NN=C(NC(CC3=NC(C)=CC(OC4CC(F)(F)C4)=C3)=O)C=C2)N=N1.[H]Cl.[H]Cl


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