IPG11406

GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases .


Cat. No.: EX-A13582	Purity: >98%

	Chemical structure of IPG11406

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
10mg	get quote
100mg	get quote
1g	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2924063-98-7
Purity	>98%
Formula	C20H18F2N4O5
Mol Weight	432.3775

Reference:	[1]. Xi J, et al. Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis. J Med Chem. 2023 Dec 14;66(23):15926-15943.
CoA	CoA of IPG11406

Smiles:	FC(O1)(F)OC2=C1C=CC(/C=C/C(N3CCN(C(C4=CN=C(OC)N=C4)=O)CC3)=O)=C2


		Search