INY-03-041

INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib conjugated to Lenalidomide . INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0, 6.8 and 3.5 nM, respectively .


Cat. No.: EX-A7894	Purity: >98%

	Chemical structure of INY-03-041

For research only, Do not use for Human!

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CAS No.	2503017-97-6
Purity	>98%
Formula	C44H56ClN7O5
Mol Weight	798.412
Color	White to off-white
State	solid powder
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>1 years if stored properly
Storage	-20°C, sealed storage, away from moisture
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. [2].Maira SM, et al. Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor. Mol Cancer Ther. 2012 Feb;11(2):317-28.
CoA	CoA of INY-03-041


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