INCB126503

INCB126503 is an orally activeM, selective FGFR2/3 Inhibitor with IC50 values of 70 nM (FGFR1), 2.1 nM (FGFR2), 1.2 nM (FGFR3), 0.92 nM (FGFR3-V555L), 0.85 nM (FGFR3-V555M) and 64 nM (FGFR4). INCB126503 suppresses FGFR signaling in vivo without causing hyperphosphatemia and shows antitumor efficacy in xenograft models harboring FGFR3 genetic alterations.


Cat. No.: EX-A13307	Purity: >98%

	Chemical structure of INCB126503

For research only, Do not use for Human!

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CAS No.	2640089-88-7
Purity	>98%
Formula	C27H30N6O2
Mol Weight	470.5661
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nguyen MH, et al. Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor. ACS Med Chem Lett. 2025 May 17;16(6):1182-1189.
CoA	CoA of INCB126503

Smiles:	CC1=CC=CC(C2=NC3=C(NN=C3C4=CN=C(N5C[C@@](C[C@@H](O)C6)([H])N6CC5)C=C4)C=C2OC)=C1C


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