INCB 3284

INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure.


Cat. No.: EX-A11027	Purity: >98%

	Chemical structure of INCB 3284

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	620	In-stock
500mg	930	In-stock
1g	1380	In-stock

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CAS No.	887401-92-5
Purity	>98%
Formula	C26H31F3N4O4
Mol Weight	520.5439
Color	Off-white to yellow
State	Solid
Solubility	DMSO : ? 83.3 mg/mL H2O : < 0.1 mg/m
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xue CB, et al. Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett. 2011 Mar 31;2(6):450-4. [2]. McMillin M, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.
CoA	CoA of INCB 3284

Smiles:	O=C(NCC(N[C@H]1CN([C@H]2CC[C@@](C3=CC=C(OC)N=C3)(O)CC2)CC1)=O)C4=CC=CC(C(F)(F)F)=C4


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