iMQT_020

iMQT_020 is a selective allosteric SLC1A5_var inhibitor. iMQT_020 disrupts the trimeric assembly of SLC1A5_var, causing metabolic crisis in cancer cells and selectively suppressing their growth. iMQT_020 reduces glutamine anaplerosis and oxidative phosphorylation, resulting in a broad disruption of cancer metabolism. iMQT_020 reduces GSH levels and increases cellular ROS and mitochondrial ROS. iMQT_020 induces apoptosis and ferroptosis. iMQT_020 can epigenetically upregulate PD-L1 expression. iMQT_020 can be used for the study of pancreatic cancer, lung cancer, and colon cancer .


Cat. No.: EX-A16433	Purity: >98%

	Chemical structure of iMQT_020

For research only, Do not use for Human!

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25mg	get quote

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CAS No.	2463893-46-9
Purity	>98%
Formula	C14H8ClFN2O3
Mol Weight	306.676
Color	White to off-white
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Sung Y, et al. Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var. Nat Commun. 2025 Nov 3;16(1):9690.
CoA	CoA of iMQT_020

Smiles:	O=C1NC(=O)C2=CC(=CC=C2N1)C=3C=C(Cl)C(O)=CC3F


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