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Product Information:

Imifoplatin

Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity .

Cat. No.: EX-A15019    Purity: >98%
Chemical
Chemical structure of Imifoplatin


For research only, Do not use for Human!

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SynonymsPT-112
CAS No.1339960-28-9
Purity>98%
FormulaC6H14N2O7P2Pt
Mol Weight483.216
ColorWhite to off-white
StateSolid
SolubilitySoluble in H2O
Shelf Life>3 years if stored properly
StoragePowder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Moghaddas S, et, al. Phosphaplatins, next generation platinum antitumor agents: A paradigm shift in designing and defining molecular targets. Inorganica Chimica Acta. 2012 Dec; 393(1): 173-181.

[2]. Yamazaki T, et al. PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models. Oncoimmunology. 2020 Feb 11;9(1):1721810.

[3]. Soler-Agesta R, et al. PT-112 induces mitochondrial stress and immunogenic cell death, targeting tumor cells with mitochondrial deficiencies[J]. Cancers, 2022, 14(16): 3851.

CoACoA of Imifoplatin
Smiles:O=[P]([O-][Pt+2]1([O-][P]2(O)=O)[NH2][C@@](CCCC3)([H])[C@]3([H])[NH2]1)(O2)O

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