Imidazole ketone erastin

Imidazole ketone erastin (IKE) is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc - and an activator of ferroptosis.


Cat. No.: EX-A3112	Purity: >98%

	Chemical structure of Imidazole ketone erastin

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	650	In-stock
500mg	1050	In-stock
1g	1550	In-stock
2g	2600	In-stock
5g	4500	In-stock
10g	7650	In-stock

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Synonyms	IKE
Synonyms 2	PUN30119
CAS No.	1801530-11-9
Purity	>98%
Formula	C35H35ClN6O5
Mol Weight	655.143
State	solid powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang, Yan et al. “Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model.” Cell chemical biology vol. 26,5 (2019): 623-633.e9. [2]. Larraufie, Marie-Helene et al. “Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.” Bioorganic & medicinal chemistry letters vol. 25,21 (2015): 4787-4792.
Data Sheet	Data sheet of Imidazole ketone erastin
CoA	CoA of Imidazole ketone erastin
SDS	SDS of Imidazole ketone erastin

Smiles:	O=C1N(C2=CC(C(CN3C=CN=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61


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