IKZF2-degrader 1

IKZF2-degrader 1 (Compound 31) is a IKZF2 molecular glue degrader, with an DC50 of 0.5 nM. IKZF2-degrader 1 has minimal CK1α degradation activity relatively (DC50: 210 nM). IKZF2-degrader 1 can be used for research of IKZF2-dependent cancers.


Cat. No.: EX-A17096	Purity: >98%

	Chemical structure of IKZF2-degrader 1

For research only, Do not use for Human!

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CAS No.	2983840-43-1
Purity	>98%
Formula	C27H30FN7O3
Mol Weight	519.5706
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang X, et al. Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders. Bioorg Med Chem Lett. 2025 May 5;124:130263.
CoA	CoA of IKZF2-degrader 1

Smiles:	CC(C)NC1=NNC2=C(CN3CCCC3)C=C(C4=C(F)C(CN(C5CCC(NC5=O)=O)C6=O)=C6C=C4)N=C21


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