(+)-Igmesine hydrochloride

Igmesine hydrochloride (JO 1784) is an orally active σ-receptor ligand capable of blocking the increase in colonic electromechanical activity induced by emotional stress. Igmesine hydrochloride also eliminates the colonic motility stimulation induced by dopamine, as well as the stimulation induced by centrally injected D1 or D2 receptor agonists. Furthermore, Igmesine hydrochloride can block the colonic motility responses induced by corticotropin-releasing factor (CRF) and ES through central cholecystokinin (CCK) release and/or activation of supraspinal CCK pathways[1][2].


Cat. No.: EX-A15402	Purity: >98%

	Chemical structure of (+)-Igmesine hydrochloride

For research only, Do not use for Human!

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Synonyms	JO 1784 hydrochloride
CAS No.	130152-35-1
Purity	>98%
Formula	C23H30ClN
Mol Weight	355.944
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gué M, et al. Reversal of CRF- and dopamine-induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the rat. Br J Pharmacol. 1994 Mar;111(3):930-4. [2]. Roman F J, et al. JO 1784, a potent and selective ligand for rat and mouse brain σ‐sites[J]. Journal of Pharmacy and Pharmacology, 1990, 42(6): 439-440.
CoA	CoA of (+)-Igmesine hydrochloride

Smiles:	CCC(C/C=C/C1=CC=CC=C1)(C2=CC=CC=C2)N(C)CC3CC3.Cl


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