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Product Information:

IDE397

IDE397 (GSK-4362676) is a potent inhibitor of MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models.

Cat. No.: EX-A8014K    Purity: >98%
Chemical
Chemical structure of IDE397


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg530in_stock
100mg704in_stock
250mg987in_stock
500mg1426in_stock
1g1913in_stock


SynonymsGSK-4362676
Synonyms 2MAT2A-IN-9
CAS No.2439277-80-0
Purity>98%
FormulaC14H8ClF3N4O
Mol Weight340.688
Statesolid powder
SolubilitySoluble in DMSO, not in water
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Marcus M. Fischer, Neil Bhola, John Faulhaber, Yevgeniy Freyman, Bing Yao, Zineb Mounir, Mark R. Lackner, Claire Neilan. MAT2A inhibitor, IDE397, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1278.

[2]. Guo, Jiamin et al. “Targeting the methionine-methionine adenosyl transferase 2A- S -adenosyl methionine axis for cancer therapy.” Current opinion in oncology vol. 34,5 (2022): 546-551.

CoACoA of IDE397
Smiles:C1=CC=C(C(=C1)N2C3=C(C=CC(=N3)C(F)(F)F)C(=NC2=O)N)Cl

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