IBG1

IBG1 (PROTAC BRD4 Degrader-19) is a PROTAC-like degrader specifically targeting BET bromodomains with a DC50 of 0.15 nM for BRD4. It consists of the BET inhibitor JQ1 linked to E7820 and functions through CRL4-DCAF16.


Cat. No.: EX-A8498	Purity: >98%

	Chemical structure of IBG1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	800	In-stock
1g	2500	In-stock
5g	get quote	Inquire

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Synonyms	PROTAC BRD4 Degrader-19
CAS No.	2684292-71-3
Purity	>98%
Formula	C44H38N8O5S2
Mol Weight	822.953
Color	White to yellow
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>1 years if stored properly
Storage	-20°C, protect from light, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A. Targeted protein degradation via intramolecular bivalent glues. Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21. PMID: 38383787; PMCID: PMC10917667. [2]. Ohba Kiyomi, et al. Medicine containing BRD4 protein degradation inducer. JP2023024381.
CoA	CoA of IBG1

Smiles:	CC1=C(C)SC2=C1C(C3=CC=C(C4=CC=C(C=C4)C(NCC5=CC=C(C=C5)S(NC6=C7C(C(C#N)=CN7)=C(C=C6)C)(=O)=O)=O)C=C3)=N[C@@H](CC(OC)=O)C8=NN=C(C)N28


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