IACS-10759

IACS-010759 is an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS.


Cat. No.: EX-A1907	Purity: >98%

	Chemical structure of IACS-10759

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	446	in_stock
500mg	763	in_stock
1g	1226	in_stock
5g	4114	inquire

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CAS No.	1570496-34-2
Purity	>98%
Formula	C25H25F3N6O4S
Mol Weight	562.564
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jennifer R Molina, et al. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 Jul;24(7):1036-1046. [2]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380
CoA	CoA of IACS-10759

Smiles:	CC1=NC(=NN1CC1=CC(=CC=C1)N1CCC(CC1)S(C)(=O)=O)C1=NC(=NO1)C1=CC=C(OC(F)(F)F)C=C1


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