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Product Information:

I-BET762 carboxylic acid

I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.

Cat. No.: EX-A3917    Purity: >98%
Chemical
Chemical structure of I-BET762 carboxylic acid


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
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250mg950Inquire
1g2350Inquire
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CAS No.1300019-38-8
Purity>98%
FormulaC20H17ClN4O3
Mol Weight396.827
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mirguet O, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56(19):7501-15.

CoACoA of I-BET762 carboxylic acid
Smiles:CC1=NN=C2[C@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21

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