HWL-088

HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects.


Cat. No.: EX-A10785	Purity: >98%

	Chemical structure of HWL-088

For research only, Do not use for Human!

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CAS No.	2378617-96-8
Purity	>98%
Formula	C22H19FO4
Mol Weight	366.3823
Color	white to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li Z, et al. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold. Bioorg Chem. 2019 Nov;92:103209. [2]. Yueming Chen, et al. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. Br J Pharmacol. 2020 May;177(10):2286-2302.
CoA	CoA of HWL-088

Smiles:	CC1=CC=CC=C1C2=CC(COC3=CC=C(OCC(O)=O)C(F)=C3)=CC=C2


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