HVH-2930

HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90). It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively.


Cat. No.: EX-A11494	Purity: >98%

	Chemical structure of HVH-2930

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	985	In-stock
250mg	1632	In-stock
500mg	2585	In-stock
1g	3985	In-stock

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CAS No.	3034605-72-3
Purity	>98%
Formula	C29H36N4O3
Mol Weight	488.6211
Color	Light yellow to yellow
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Park, Minsu et al. “The HSP90 inhibitor HVH-2930 exhibits potent efficacy against trastuzumab-resistant HER2-positive breast cancer.” Theranostics vol. 14,6 2442-2463. 31 Mar. 2024, doi:10.7150/thno.93236 [2]. La, Minh Thanh et al. “Discovery of indazole inhibitors for heat shock protein 90 as anti-cancer agents.” European journal of medicinal chemistry vol. 276 (2024): 116620. doi:10.1016/j.ejmech.2024.116620
CoA	CoA of HVH-2930

Smiles:	O=C(NC=1C=CC=2C(=NN(C2C1)CCC3CCN(C)CC3)C)C4=CC=C5OC(C=CC5=C4OC)(C)C


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