HTL14242

HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively. HTL14242 can be used for the research of parkinson's disease.


Cat. No.: EX-A5085	Purity: >98%

	Chemical structure of HTL14242

For research only, Do not use for Human!

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Synonyms	HTL0014242
CAS No.	1644645-32-8
Purity	>98%
Formula	C16H8ClFN4
Mol Weight	310.713
Color	White to yellow
State	solid powder
Solubility	Soluble in DMSO 12.5 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kirstie A Bennett, et al. Structure-based Discovery and Development of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Adv Pharmacol. . 2020;88:35-58. [2]. John A Christopher, et al. Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J Med Chem. . 2015 Aug 27;58(16):6653-64.
CoA	CoA of HTL14242

Smiles:	N#CC1=CC(C2=NC=NC(C3=NC=C(F)C=C3)=C2)=CC(Cl)=C1


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