HSP90-IN-31

HSP90-IN-31 (compound Be01) causes reduction of CD80 and CD86 expression on dendritic cells (DCs). HSP90-IN-31 decreases the production of pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) in BMDC and peritoneal macrophages stimulated by LPS. Under the delayed-type hypersensitivity (DTH) mice model, HSP90-IN-31 reduces ear swelling and pro-inflammatory cytokines in the spleen.


Cat. No.: EX-A13330	Purity: >98%

	Chemical structure of HSP90-IN-31

For research only, Do not use for Human!

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CAS No.	2117645-10-8
Purity	>98%
Formula	C22H28N2O4
Mol Weight	384.4687
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hyun Bo Sim, et al. Development of Hsp90 inhibitor to regulate cytokine storms in excessive delayed- and acute inflammation. Int Immunopharmacol. 2024 Aug 20:137:112470.
CoA	CoA of HSP90-IN-31

Smiles:	CC(C)C1=C(O)C=C(O)C(C(N(C)CC2=CC=C(C(NCCC)=O)C=C2)=O)=C1


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