HSN748

HSN748 is a Ponatinib analogue and a multikinase inhibitor. HSN748 has inhibitory activity on FLT3, ABL1, RET, PDGFRα/β, MNK1, MNK2 and other kinases. HSN748 can inhibit the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines and can be used in the study of leukemia.


Cat. No.: EX-A12402	Purity: >98%

	Chemical structure of HSN748

For research only, Do not use for Human!

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CAS No.	2409925-53-5
Purity	>98%
Formula	C27H24F3N7O
Mol Weight	519.521
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kumar A, et al. Specificity of the Redox Complex between Cytochrome P450 24A1 and Adrenodoxin Relies on Carbon-25 Hydroxylation of Vitamin-D Substrate. Drug Metab Dispos. 2019 Sep;47(9):974-982.
CoA	CoA of HSN748

Smiles:	O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)C=3C=NC=C(C#CC4=CN=C5C=CC=NN45)C3


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