HS-243

HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC50 of 0.5 μM.


Cat. No.: EX-A4799	Purity: 98+%

	Chemical structure of HS-243

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	465	In-stock
250mg	785	In-stock
1g	1185	In-stock

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CAS No.	848249-10-5
Purity	98+%
Formula	C17H16N4O3
Mol Weight	324.3339
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Scarneo SA, et al. A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. J Biol Chem. 2020 Feb 7;295(6):1565-1574.
CoA	CoA of HS-243

Smiles:	CCCN1C2=CC=CC=C2N/C1=N\C(C3=CC([N+]([O-])=O)=CC=C3)=O


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