HRS-4642

HRS-4642 is a selective KRAS(G12D) inhibitor (Kd=0.083 nM) with anti-cancer activity. HRS-4642 synergizes with Carfilzomib and exhibits significant in vivo potency to reshape the tumor microenvironment into an immune-activating microenvironment.


Cat. No.: EX-A10284	Purity: >98%

	Chemical structure of HRS-4642

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	3980	In-stock
250mg	get quote	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

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CAS No.	2836263-09-1
Purity	>98%
Formula	C34H35F3N6O3
Mol Weight	632.6753
Color	white to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhou C, et al. Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer. Cancer Cell. 2024 Jul 8;42(7):1286-1300.e8.
CoA	CoA of HRS-4642

Smiles:	OC(C=C1C2=C(F)C(N=C(OC[C@@]3(CCC4)N4C[C@H](F)C3)N=C5N(C[C@@H]6N[C@H]7CC6)[C@@H]7CO8)=C5C8=N2)=CC9=C1C(CC)=C(F)C=C9


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